Genetic replacement of surfactant protein-C reduces respiratory syncytial virus induced lung injury

BACKGROUND: Individuals with deficiencies of pulmonary surfactant protein C (SP-C) develop interstitial lung disease (ILD) that is exacerbated by viral infections including respiratory syncytial virus (RSV). SP-C gene targeted mice (Sftpc -/-) lack SP-C, develop an ILD-like disease and are susceptib...

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Autori principali: Glasser, Stephan W, Senft, Albert P, Maxfield, Melissa D, Ruetschilling, Teah L, Baatz, John E, Page, Kristen, Korfhagen, Thomas R
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2013
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3598668/
https://ncbi.nlm.nih.gov/pubmed/23399055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1465-9921-14-19
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