Characterization of the BCR promoter in Philadelphia chromosome-positive and -negative cell lines.

The t(9;22) Philadelphia chromosome translocation fuses 5' regulatory and coding sequences of the BCR gene to the c-ABL proto-oncogene. This results in the formation of hybrid BCR-ABL mRNAs and proteins. The shift in ABL transcriptional control to the BCR promoter may play a role in cellular tr...

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Bibliographic Details
Main Authors: Shah, N P, Witte, O N, Denny, C T
Format: Artigo
Language:Inglês
Published: 1991
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC359860/
https://ncbi.nlm.nih.gov/pubmed/1900918
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