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BCR first exon sequences specifically activate the BCR/ABL tyrosine kinase oncogene of Philadelphia chromosome-positive human leukemias.

The c-abl proto-oncogene encodes a cytoplasmic tyrosine kinase which is homologous to the src gene product in its kinase domain and in the upstream kinase regulatory domains SH2 (src homology region 2) and SH3 (src homology region 3). The murine v-abl oncogene product has lost the SH3 domain as a co...

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Udgivet i:Mol Cell Biol
Principais autores: Muller, A J, Young, J C, Pendergast, A M, Pondel, M, Landau, N R, Littman, D R, Witte, O N
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 1991
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC359845/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2005881/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.11.4.1785-1792.1991
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