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Familial cosegregation of rare genetic variants with disease in complex disorders
Family-based designs are increasingly being used for identification of rare variants in complex disorders. This paper addresses two questions related to the utility of these designs. First, under what circumstances are rare disease-related variants expected to cosegregate with disease in families? S...
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| Main Authors: | , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Nature Publishing Group
2013
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3598309/ https://ncbi.nlm.nih.gov/pubmed/23010752 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ejhg.2012.194 |
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