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High dose folic acid supplementation of rats alters synaptic transmission and seizure susceptibility in offspring

Maternal folic acid supplementation is essential to reduce the risk of neural tube defects. We hypothesize that high levels of folic acid throughout gestation may produce neural networks more susceptible to seizure in offspring. We hence administered large doses of folic acid to rats before and duri...

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Détails bibliographiques
Auteurs principaux: Girotto, Fernando, Scott, Lucas, Avchalumov, Yosef, Harris, Jacqueline, Iannattone, Stephanie, Drummond-Main, Chris, Tobias, Rose, Bello-Espinosa, Luis, Rho, Jong M., Davidsen, Jörn, Teskey, G. Campbell, Colicos, Michael A.
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2013
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3598003/
https://ncbi.nlm.nih.gov/pubmed/23492951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep01465
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