High dose folic acid supplementation of rats alters synaptic transmission and seizure susceptibility in offspring

Maternal folic acid supplementation is essential to reduce the risk of neural tube defects. We hypothesize that high levels of folic acid throughout gestation may produce neural networks more susceptible to seizure in offspring. We hence administered large doses of folic acid to rats before and duri...

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Main Authors: Girotto, Fernando, Scott, Lucas, Avchalumov, Yosef, Harris, Jacqueline, Iannattone, Stephanie, Drummond-Main, Chris, Tobias, Rose, Bello-Espinosa, Luis, Rho, Jong M., Davidsen, Jörn, Teskey, G. Campbell, Colicos, Michael A.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2013
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3598003/
https://ncbi.nlm.nih.gov/pubmed/23492951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep01465
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