B-Raf is required for positive selection and survival of DP cells, but not for negative selection of SP cells

The duration of signaling through the MAP kinase (or ERK pathway) cascade has been implicated in thymic development, particularly positive and negative selection. In T cells, two isoforms of the MAP kinase kinase kinase Raf function to transmit signals from the T-cell receptor to ERK: C-Raf and B-Ra...

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Detalhes bibliográficos
Principais autores: Dillon, Tara J., Takahashi, Maho, Li, Yanping, Tavisala, Srilatha, Murray, Susan E., Moran, Amy E., Parker, David C., Stork, Philip J. S.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2013
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3597848/
https://ncbi.nlm.nih.gov/pubmed/23334952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/intimm/dxs104
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