Tumor-derived Mutations in the Gene Associated with Retinoid Interferon-induced Mortality (GRIM-19) Disrupt Its Anti-signal Transducer and Activator of Transcription 3 (STAT3) Activity and Promote Oncogenesis

The signal transducer and activator of transcription 3 (STAT3) protein is critical for multiple cytokine and growth factor-induced biological responses in vivo. Its transcriptional activity is controlled by a transient phosphorylation of a critical tyrosine. Constitutive activation of STAT3 imparts...

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Bibliographische Detailangaben
Hauptverfasser: Nallar, Shreeram C., Kalakonda, Sudhakar, Lindner, Daniel J., Lorenz, Robert R., Lamarre, Eric, Weihua, Xiao, Kalvakolanu, Dhananjaya V.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2013
Schlagworte:
Molecular Bases of Disease
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3597830/
https://ncbi.nlm.nih.gov/pubmed/23386605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.440610
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