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Topology of NBCe1 Protein Transmembrane Segment 1 and Structural Effect of Proximal Renal Tubular Acidosis (pRTA) S427L Mutation

In the kidney proximal tubule, NBCe1-A plays a critical role in absorbing HCO(3)(−) from cell to blood. NBCe1-A transmembrane segment 1 (TM1) is involved in forming part of the ion permeation pathway, and a missense mutation S427L in TM1 impairs ion transport, causing proximal renal tubular acidosis...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Zhu, Quansheng, Liu, Weixin, Kao, Liyo, Azimov, Rustam, Newman, Debra, Abuladze, Natalia, Kurtz, Ira
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Society for Biochemistry and Molecular Biology 2013
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC3597827/
https://ncbi.nlm.nih.gov/pubmed/23362273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.404533
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