Transforming Growth Factor β Integrates Smad 3 to Mechanistic Target of Rapamycin Complexes to Arrest Deptor Abundance for Glomerular Mesangial Cell Hypertrophy

In many renal diseases, transforming growth factor β (TGFβ)-stimulated canonical Smad 3 and noncanonical mechanistic target of rapamycin (mTOR) promote increased protein synthesis and mesangial cell hypertrophy. The cellular underpinnings involving these signaling molecules to regulate mesangial cel...

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Bibliographische Detailangaben
Hauptverfasser: Das, Falguni, Ghosh-Choudhury, Nandini, Bera, Amit, Dey, Nirmalya, Abboud, Hanna E., Kasinath, Balakuntalam S., Choudhury, Goutam Ghosh
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2013
Schlagworte:
Molecular Bases of Disease
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3597815/
https://ncbi.nlm.nih.gov/pubmed/23362262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.455782
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