The Presence of HIV-1 Tat Protein Second Exon Delays Fas Protein-mediated Apoptosis in CD4(+) T Lymphocytes: A POTENTIAL MECHANISM FOR PERSISTENT VIRAL PRODUCTION

HIV-1 replication is efficiently controlled by the regulator protein Tat (101 amino acids) and codified by two exons, although the first exon (1–72 amino acids) is sufficient for this process. Tat can be released to the extracellular medium, acting as a soluble pro-apoptotic factor in neighboring ce...

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Detalhes bibliográficos
Main Authors: López-Huertas, María Rosa, Mateos, Elena, Sánchez del Cojo, María, Gómez-Esquer, Francisco, Díaz-Gil, Gema, Rodríguez-Mora, Sara, López, Juan Antonio, Calvo, Enrique, López-Campos, Guillermo, Alcamí, José, Coiras, Mayte
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3597804/
https://ncbi.nlm.nih.gov/pubmed/23364796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.408294
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