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Replacement of All Arginine Residues with Canavanine in MazF-bs mRNA Interferase Changes Its Specificity
Replacement of a specific amino acid residue in a protein with nonnatural analogues is highly challenging because of their cellular toxicity. We demonstrate for the first time the replacement of all arginine (Arg) residues in a protein with canavanine (Can), a toxic Arg analogue. All Arg residues in...
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Biochemistry and Molecular Biology
2013
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3597797/ https://ncbi.nlm.nih.gov/pubmed/23378533 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.434969 |
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