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Replacement of All Arginine Residues with Canavanine in MazF-bs mRNA Interferase Changes Its Specificity

Replacement of a specific amino acid residue in a protein with nonnatural analogues is highly challenging because of their cellular toxicity. We demonstrate for the first time the replacement of all arginine (Arg) residues in a protein with canavanine (Can), a toxic Arg analogue. All Arg residues in...

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Main Authors: Ishida, Yojiro, Park, Jung-Ho, Mao, Lili, Yamaguchi, Yoshihiro, Inouye, Masayori
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Biochemistry and Molecular Biology 2013
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גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3597797/
https://ncbi.nlm.nih.gov/pubmed/23378533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.434969
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