Llwytho...
In the absence of ATPase activity, pre-RC formation is blocked prior to MCM2–7 hexamer dimerization
The origin recognition complex (ORC) of Saccharomyces cerevisiae binds origin DNA and cooperates with Cdc6 and Cdt1 to load the replicative helicase MCM2–7 onto DNA. Helicase loading involves two MCM2–7 hexamers that assemble into a double hexamer around double-stranded DNA. This reaction requires O...
Wedi'i Gadw mewn:
| Prif Awduron: | , , , , , , , , |
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| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
Oxford University Press
2013
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| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3597701/ https://ncbi.nlm.nih.gov/pubmed/23376927 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt043 |
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