In the absence of ATPase activity, pre-RC formation is blocked prior to MCM2–7 hexamer dimerization

The origin recognition complex (ORC) of Saccharomyces cerevisiae binds origin DNA and cooperates with Cdc6 and Cdt1 to load the replicative helicase MCM2–7 onto DNA. Helicase loading involves two MCM2–7 hexamers that assemble into a double hexamer around double-stranded DNA. This reaction requires O...

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Hlavní autoři: Evrin, Cecile, Fernández-Cid, Alejandra, Zech, Juergen, Herrera, M. Carmen, Riera, Alberto, Clarke, Pippa, Brill, Shlomo, Lurz, Rudi, Speck, Christian
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2013
Témata:
Genome Integrity, Repair and Replication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3597701/
https://ncbi.nlm.nih.gov/pubmed/23376927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt043
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