MSH6- or PMS2-deficiency causes re-replication in DT40 B cells, but it has little effect on immunoglobulin gene conversion or on repair of AID-generated uracils

The mammalian antibody repertoire is shaped by somatic hypermutation (SHM) and class switch recombination (CSR) of the immunoglobulin (Ig) loci of B lymphocytes. SHM and CSR are triggered by non-canonical, error-prone processing of G/U mismatches generated by activation-induced deaminase (AID). In b...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Campo, Vanina A., Patenaude, Anne-Marie, Kaden, Svenja, Horb, Lori, Firka, Daniel, Jiricny, Josef, Di Noia, Javier M.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2013
Assuntos:
Genome Integrity, Repair and Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3597665/
https://ncbi.nlm.nih.gov/pubmed/23314153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks1470
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados