rDNA-directed integration by an HIV-1 integrase—I-PpoI fusion protein

Integrating viral vectors are efficient gene transfer tools, but their integration patterns have been associated with genotoxicity and oncogenicity. The recent development of highly specific designer nucleases has enabled target DNA modification and site-specific gene insertion at desired genomic lo...

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Bibliografske podrobnosti
Main Authors: Schenkwein, Diana, Turkki, Vesa, Ahlroth, Mervi K., Timonen, Oskari, Airenne, Kari J., Ylä-Herttuala, Seppo
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2013
Teme:
Methods Online
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3597653/
https://ncbi.nlm.nih.gov/pubmed/23275537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks1438
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