rDNA-directed integration by an HIV-1 integrase—I-PpoI fusion protein

Integrating viral vectors are efficient gene transfer tools, but their integration patterns have been associated with genotoxicity and oncogenicity. The recent development of highly specific designer nucleases has enabled target DNA modification and site-specific gene insertion at desired genomic lo...

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Библиографические подробности
Главные авторы: Schenkwein, Diana, Turkki, Vesa, Ahlroth, Mervi K., Timonen, Oskari, Airenne, Kari J., Ylä-Herttuala, Seppo
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2013
Предметы:
Methods Online
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3597653/
https://ncbi.nlm.nih.gov/pubmed/23275537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks1438
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