rDNA-directed integration by an HIV-1 integrase—I-PpoI fusion protein

Integrating viral vectors are efficient gene transfer tools, but their integration patterns have been associated with genotoxicity and oncogenicity. The recent development of highly specific designer nucleases has enabled target DNA modification and site-specific gene insertion at desired genomic lo...

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Bibliographic Details
Main Authors: Schenkwein, Diana, Turkki, Vesa, Ahlroth, Mervi K., Timonen, Oskari, Airenne, Kari J., Ylä-Herttuala, Seppo
Format: Artigo
Language:Inglês
Published: Oxford University Press 2013
Subjects:
Methods Online
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3597653/
https://ncbi.nlm.nih.gov/pubmed/23275537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks1438
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