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rDNA-directed integration by an HIV-1 integrase—I-PpoI fusion protein

Integrating viral vectors are efficient gene transfer tools, but their integration patterns have been associated with genotoxicity and oncogenicity. The recent development of highly specific designer nucleases has enabled target DNA modification and site-specific gene insertion at desired genomic lo...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Schenkwein, Diana, Turkki, Vesa, Ahlroth, Mervi K., Timonen, Oskari, Airenne, Kari J., Ylä-Herttuala, Seppo
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2013
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3597653/
https://ncbi.nlm.nih.gov/pubmed/23275537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks1438
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