Growth factor independence-1 antagonizes a p53-induced DNA damage response pathway in lymphoblastic leukemia

Most patients with acute lymphoblastic leukemia (ALL) fail current treatments highlighting the need for better therapies. Since oncogenic signaling activates a p53-dependent DNA-damage response and apoptosis, leukemic cells must devise appropriate countermeasures. We show here that growth factor ind...

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Autors principals: Khandanpour, Cyrus, Phelan, James D., Vassen, Lothar, Schütte, Judith, Chen, Riyan, Horman, Shane R., Gaudreau, Marie-Claude, Krongold, Joseph, Zhu, Jinfang, Paul, William E., Dührsen, Ulrich, Göttgens, Bertie, Grimes, H. Leighton, Möröy, Tarik
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3597385/
https://ncbi.nlm.nih.gov/pubmed/23410974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2013.01.011
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