Zinc Finger Protein Gfi1 Controls the Endotoxin-Mediated Toll-Like Receptor Inflammatory Response by Antagonizing NF-κB p65

Endotoxin (bacterial lipopolysaccharide [LPS]) causes fatal septic shock via the Toll-like receptor 4 (TLR-4) protein present on innate immunity effector cells, which activates nuclear factor kappa B (NF-κB), inducing proinflammatory cytokines, including tumor necrosis factor alpha (TNF-α). An early...

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Autors principals: Sharif-Askari, Ehssan, Vassen, Lothar, Kosan, Christian, Khandanpour, Cyrus, Gaudreau, Marie-Claude, Heyd, Florian, Okayama, Taro, Jin, Jianmin, Rojas, Meghan E. B., Grimes, H. Leighton, Zeng, Hui, Möröy, Tarik
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 2010
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2916436/
https://ncbi.nlm.nih.gov/pubmed/20547752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00087-10
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