Prevention of JNK phosphorylation as a mechanism for rosiglitazone in neuroprotection after transient cerebral ischemia: activation of dual specificity phosphatase

Rosiglitazone, a synthetic peroxisome proliferator-activated receptor-γ (PPARγ) agonist, prevents cell death after cerebral ischemia in animal models, but the underlying mechanism has not been clarified. In this study, we examined how rosiglitazone protects neurons against ischemia. Mice treated wit...

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Bibliografiske detaljer
Main Authors: Okami, Nobuya, Narasimhan, Purnima, Yoshioka, Hideyuki, Sakata, Hiroyuki, Kim, Gab Seok, Jung, Joo Eun, Maier, Carolina M, Chan, Pak H
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2013
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3597369/
https://ncbi.nlm.nih.gov/pubmed/23032483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2012.138
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