Inhibition of peptidyl-arginine deiminases reverses protein-hypercitrullination and disease in mouse models of multiple sclerosis

Multiple sclerosis (MS) is the most common CNS-demyelinating disease of humans, showing clinical and pathological heterogeneity and a general resistance to therapy. We first discovered that abnormal myelin hypercitrullination, even in normal-appearing white matter, by peptidylarginine deiminases (PA...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Moscarello, Mario A., Lei, Helena, Mastronardi, Fabrizio G., Winer, Shawn, Tsui, Hubert, Li, Zhen, Ackerley, Cameron, Zhang, Li, Raijmakers, Reinout, Wood, D. Denise
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The Company of Biologists Limited 2013
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3597028/
https://ncbi.nlm.nih.gov/pubmed/23118341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.010520
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