Peptidylarginine deiminase 2 (PAD2) overexpression in transgenic mice leads to myelin loss in the central nervous system

Demyelination in the central nervous system is the hallmark feature in multiple sclerosis (MS). The mechanism resulting in destabilization of myelin is a complex multi-faceted process, part of which involves deimination of myelin basic protein (MBP). Deimination, the conversion of protein-bound argi...

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Detalhes bibliográficos
Main Authors: Musse, Abdiwahab A., Li, Zhen, Ackerley, Cameron A., Bienzle, Dorothee, Lei, Helena, Poma, Roberto, Harauz, George, Moscarello, Mario A., Mastronardi, Fabrizio G.
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists Limited 2008
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2590822/
https://ncbi.nlm.nih.gov/pubmed/19093029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.000729
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