Erythrocyte NADPH oxidase activity modulated by Rac GTPases, PKC, and plasma cytokines contributes to oxidative stress in sickle cell disease

Chronic inflammation has emerged as an important pathogenic mechanism in sickle cell disease (SCD). One component of this inflammatory response is oxidant stress mediated by reactive oxygen species (ROS) generated by leukocytes, endothelial cells, plasma enzymes, and sickle red blood cells (RBC). Si...

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Bibliografski detalji
Glavni autori: George, Alex, Pushkaran, Suvarnamala, Konstantinidis, Diamantis G., Koochaki, Sebastian, Malik, Punam, Mohandas, Narla, Zheng, Yi, Joiner, Clinton H., Kalfa, Theodosia A.
Format: Artigo
Jezik:Inglês
Izdano: American Society of Hematology 2013
Teme:
Red Cells, Iron, and Erythropoiesis
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3596970/
https://ncbi.nlm.nih.gov/pubmed/23349388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-07-441188
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