Altered Phosphorylation of Cytoskeleton Proteins in Sickle Red Blood Cells: The Role of Protein Kinase C, Rac GTPases, and Reactive Oxygen Species

The small Rho GTPases Rac1 and Rac2 regulate actin structures and mediate reactive oxygen species (ROS) production via NADPH oxidase in a variety of cells. We have demonstrated that deficiency of Rac1 and Rac2 GTPases in mice disrupts the normal hexagonal organization of the RBC cytoskeleton and red...

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Библиографические подробности
Главные авторы: George, Alex, Pushkaran, Suvarnamala, Li, Lina, An, Xiuli, Zheng, Yi, Mohandas, Narla, Joiner, Clinton H., Kalfa, Theodosia A.
Формат: Artigo
Язык:Inglês
Опубликовано: 2010
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2878931/
https://ncbi.nlm.nih.gov/pubmed/20231105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcmd.2010.02.006
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