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Altered Phosphorylation of Cytoskeleton Proteins in Sickle Red Blood Cells: The Role of Protein Kinase C, Rac GTPases, and Reactive Oxygen Species
The small Rho GTPases Rac1 and Rac2 regulate actin structures and mediate reactive oxygen species (ROS) production via NADPH oxidase in a variety of cells. We have demonstrated that deficiency of Rac1 and Rac2 GTPases in mice disrupts the normal hexagonal organization of the RBC cytoskeleton and red...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2010
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2878931/ https://ncbi.nlm.nih.gov/pubmed/20231105 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcmd.2010.02.006 |
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