Dosage-dependent tumor suppression by histone deacetylases 1 and 2 through regulation of c-Myc collaborating genes and p53 function

Histone deacetylases (HDACs) are epigenetic erasers of lysine-acetyl marks. Inhibition of HDACs using small molecule inhibitors (HDACi) is a potential strategy in the treatment of various diseases and is approved for treating hematological malignancies. Harnessing the therapeutic potential of HDACi...

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Main Authors: Heideman, Marinus R., Wilting, Roel H., Yanover, Eva, Velds, Arno, de Jong, Johann, Kerkhoven, Ron M., Jacobs, Heinz, Wessels, Lodewyk F., Dannenberg, Jan-Hermen
格式: Artigo
語言:Inglês
出版: American Society of Hematology 2013
主題:
Lymphoid Neoplasia
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3596963/
https://ncbi.nlm.nih.gov/pubmed/23327920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-08-450916
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