Synthesis and evaluation of new radioligands [(11)C]A-833834 and [(11)C]A-752274 for positron-emission tomography of α7-nicotinic acetylcholine receptors

INTRODUCTION: α7-nicotinic acetylcholine receptor (α7-nAChR) is one of the major neuronal nAChR subtypes. α7-nAChR is involved in variety of neuronal processes and disorders including schizophrenia and Alzheimer’s disease. A number of α7-nAChR PET radioligands have been developed, but a quality radi...

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Autors principals: Horti, Andrew G., Ravert, Hayden T., Gao, Yongjun, Holt, Daniel P., Bunnelle, William H., Schrimpf, Michael R., Li, Tao, Ji, Jianguo, Valentine, Heather, Scheffel, Ursula, Kuwabara, Hiroto, Wong, Dean F., Dannals, Robert F.
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3596482/
https://ncbi.nlm.nih.gov/pubmed/23294899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nucmedbio.2012.11.013
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