Synthesis and evaluation of new radioligands [(11)C]A-833834 and [(11)C]A-752274 for positron-emission tomography of α7-nicotinic acetylcholine receptors

INTRODUCTION: α7-nicotinic acetylcholine receptor (α7-nAChR) is one of the major neuronal nAChR subtypes. α7-nAChR is involved in variety of neuronal processes and disorders including schizophrenia and Alzheimer’s disease. A number of α7-nAChR PET radioligands have been developed, but a quality radi...

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Main Authors: Horti, Andrew G., Ravert, Hayden T., Gao, Yongjun, Holt, Daniel P., Bunnelle, William H., Schrimpf, Michael R., Li, Tao, Ji, Jianguo, Valentine, Heather, Scheffel, Ursula, Kuwabara, Hiroto, Wong, Dean F., Dannals, Robert F.
Format: Artigo
Language:Inglês
Published: 2013
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3596482/
https://ncbi.nlm.nih.gov/pubmed/23294899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nucmedbio.2012.11.013
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