5-(5-(6-[(11)C]methyl-3,6-diazabicyclo[3.2.0]heptan-3-yl)pyridin-2-yl)-1H-indole as a potential PET radioligand for imaging cerebral α7-nAChR in mice

The radiosynthesis and in vivo evaluation of 5-(5-(6-[(11)C]methyl-3,6-diazabicyclo[3.2.0]heptan-3-yl)pyridin-2-yl)-1H-indole [(11)C]rac-(1), a potential PET tracer for α7 nicotinic acetylcholine receptors (α7-nAChR), are described. Syntheses of the nonradioactive standard rac-1 and corresponding de...

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Detalhes bibliográficos
Main Authors: Gao, Yongjun, Ravert, Hayden T., Valentine, Heather, Scheffel, Ursula, Finley, Paige, Wong, Dean F., Dannals, Robert F., Horti, Andrew G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3527104/
https://ncbi.nlm.nih.gov/pubmed/22608919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2012.04.056
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