Tripolin A, a Novel Small-Molecule Inhibitor of Aurora A Kinase, Reveals New Regulation of HURP's Distribution on Microtubules

Mitotic regulators exhibiting gain of function in tumor cells are considered useful cancer therapeutic targets for the development of small-molecule inhibitors. The human Aurora kinases are a family of such targets. In this study, from a panel of 105 potential small-molecule inhibitors, two compound...

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Autori principali: Kesisova, Iliana A., Nakos, Konstantinos C., Tsolou, Avgi, Angelis, Dimitrios, Lewis, Joe, Chatzaki, Aikaterini, Agianian, Bogos, Giannis, Athanassios, Koffa, Maria D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2013
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3596387/
https://ncbi.nlm.nih.gov/pubmed/23516487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0058485
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