Kinetic and Structural Evidences on Human Prolidase Pathological Mutants Suggest Strategies for Enzyme Functional Rescue

Prolidase is the only human enzyme responsible for the digestion of iminodipeptides containing proline or hydroxyproline at their C-terminal end, being a key player in extracellular matrix remodeling. Prolidase deficiency (PD) is an intractable loss of function disease, characterized by mutations in...

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Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Besio, Roberta, Gioia, Roberta, Cossu, Federica, Monzani, Enrico, Nicolis, Stefania, Cucca, Lucia, Profumo, Antonella, Casella, Luigi, Tenni, Ruggero, Bolognesi, Martino, Rossi, Antonio, Forlino, Antonella
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Public Library of Science 2013
Θέματα:
Research Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3596340/
https://ncbi.nlm.nih.gov/pubmed/23516557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0058792
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