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The action of cytochrome b(5) on both CYP2E1 and CYP2C19 activities requires the anionic residues D58 and D65
The capacity of cytochrome b(5) (b(5)) to influence cytochrome P450 activities has been extensively studied and physiologically validated. Apo-b(5) enhances the activities of CYP3A4, CYP2A6, CYP2C19, and CYP17A1 but not of CYP2E1 or CYP2D6, suggesting that the b(5) interaction varies amongst P450s....
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2012
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3596112/ https://ncbi.nlm.nih.gov/pubmed/23193974 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi301384n |
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