SAMHD1 is the dendritic– and myeloid–cell–specific HIV–1 restriction factor counteracted by Vpx

The primate lentivirus auxiliary protein Vpx counteracts an unknown restriction factor that renders human dendritic and myeloid cells largely refractory to HIV-1 infection(1-6). Here we identify SAMHD1 as this restriction factor. SAMHD1 is a protein involved in Aicardi–Goutières syndrome, a genetic...

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Main Authors: Laguette, Nadine, Sobhian, Bijan, Casartelli, Nicoletta, Ringeard, Mathieu, Chable-Bessia, Christine, Ségéral, Emmanuel, Yatim, Ahmad, Emiliani, Stéphane, Schwartz, Olivier, Benkirane, Monsef
Format: Artigo
Jezik:Inglês
Izdano: 2011
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3595993/
https://ncbi.nlm.nih.gov/pubmed/21613998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature10117
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