SAMHD1 is the dendritic– and myeloid–cell–specific HIV–1 restriction factor counteracted by Vpx

The primate lentivirus auxiliary protein Vpx counteracts an unknown restriction factor that renders human dendritic and myeloid cells largely refractory to HIV-1 infection(1-6). Here we identify SAMHD1 as this restriction factor. SAMHD1 is a protein involved in Aicardi–Goutières syndrome, a genetic...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Laguette, Nadine, Sobhian, Bijan, Casartelli, Nicoletta, Ringeard, Mathieu, Chable-Bessia, Christine, Ségéral, Emmanuel, Yatim, Ahmad, Emiliani, Stéphane, Schwartz, Olivier, Benkirane, Monsef
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2011
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3595993/
https://ncbi.nlm.nih.gov/pubmed/21613998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature10117
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