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Role of EZH2 in Epithelial Ovarian Cancer: From Biological Insights to Therapeutic Target
EZH2 is the catalytic subunit of polycomb repressive complex 2 (PRC2), which generates a methylation epigenetic mark at lysine 27 residue of histone H3 (H3K27me3) to silence gene expression. EZH2 target genes are involved in a variety of biological processes such as stem cell pluripotency, cell prol...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Frontiers Media S.A.
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3595978/ https://ncbi.nlm.nih.gov/pubmed/23494175 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2013.00047 |
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