Surface-Modified HK:siRNA Nanoplexes with Enhanced Pharmacokinetics and Tumor Growth Inhibition

[Image: see text] We characterized in this study the pharmacokinetics and antitumor efficacy of histidine-lysine (HK):siRNA nanoplexes modified with PEG and a cyclic RGD (cRGD) ligand targeting αvβ3 and αvβ5 integrins. With noninvasive imaging, systemically administered surface-modified HK:siRNA nan...

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Autori principali: Chou, Szu-Ting, Leng, Qixin, Scaria, Puthupparampil, Kahn, Jason D., Tricoli, Lucas J., Woodle, Martin, Mixson, A. James
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2013
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3595641/
https://ncbi.nlm.nih.gov/pubmed/23360232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bm3018356
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