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AAV-Mediated Gene Therapy for Retinal Degeneration in the rd10 Mouse Containing a Recessive PDEβ Mutation

PURPOSE: To test AAV-mediated gene therapy in the rd10 mouse, a natural model of recessive RP caused by mutation of the β-subunit of rod photoreceptor cGMP phosphodiesterase. METHODS: One eye of a cohort of rd10 mice kept in a dark environment was subretinally injected at postnatal day (P) 14 with 1...

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Autors principals: Pang, Ji-jing, Boye, Sanford L., Kumar, Ashok, Dinculescu, Astra, Deng, Wentao, Li, Jie, Li, Qiuhong, Rani, Asha, Foster, Thomas C., Chang, Bo, Hawes, Norman L., Boatright, Jeffrey H., Hauswirth, William W.
Format: Artigo
Idioma:Inglês
Publicat: 2008
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3595574/
https://ncbi.nlm.nih.gov/pubmed/18586879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.07-1622
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