Long-term Retinal Function and Structure Rescue Using Capsid Mutant AAV8 Vector in the rd10 Mouse, a Model of Recessive Retinitis Pigmentosa

The retinal degeneration 10 (rd10) mouse is a well-characterized model of autosomal recessive retinitis pigmentosa (RP), which carries a spontaneous mutation in the β subunit of rod cGMP-phosphodiesterase (PDEβ). Rd10 mouse exhibits photoreceptor dysfunction and rapid rod photoreceptor degeneration...

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Bibliographische Detailangaben
Hauptverfasser: Pang, Ji-jing, Dai, Xufeng, Boye, Shannon E, Barone, Ilaria, Boye, Sanford L, Mao, Song, Everhart, Drew, Dinculescu, Astra, Liu, Li, Umino, Yumiko, Lei, Bo, Chang, Bo, Barlow, Robert, Strettoi, Enrica, Hauswirth, William W
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2011
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3034861/
https://ncbi.nlm.nih.gov/pubmed/21139570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2010.273
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