ASPP1 and ASPP2 bind active RAS, potentiate RAS signalling and enhance p53 activity in cancer cells

RAS mutations occur frequently in human cancer and activated RAS signalling contributes to tumour development and progression. Apart from its oncogenic effects on cell growth, active RAS has tumour-suppressive functions via its ability to induce cellular senescence and apoptosis. RAS is known to ind...

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Detalhes bibliográficos
Main Authors: Wang, Y, Godin-Heymann, N, Dan Wang, X, Bergamaschi, D, Llanos, S, Lu, X
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
Assuntos:
Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3595493/
https://ncbi.nlm.nih.gov/pubmed/23392125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2013.3
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