Human oncoprotein MDM2 activates the Akt signaling pathway through an interaction with the repressor element-1 silencing transcription factor conferring a survival advantage to cancer cells

The current paradigm states that the Akt signaling pathway phosphorylates the human oncoprotein mouse double minute 2 (MDM2), leading to its nuclear translocation and degradation of the tumor suppressor p53. Here we report a novel Akt signaling pathway elicited by MDM2. Upregulation of endogenous MD...

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Detalhes bibliográficos
Main Authors: Singh, S, Ramamoorthy, M, Vaughan, C, Yeudall, W A, Deb, S, Palit Deb, S
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
Assuntos:
Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3595481/
https://ncbi.nlm.nih.gov/pubmed/23238568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2012.153
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