Insulin analog with additional disulfide bond has increased stability and preserved activity

Insulin is a key hormone controlling glucose homeostasis. All known vertebrate insulin analogs have a classical structure with three 100% conserved disulfide bonds that are essential for structural stability and thus the function of insulin. It might be hypothesized that an additional disulfide bond...

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Main Authors: Vinther, Tine N, Norrman, Mathias, Ribel, Ulla, Huus, Kasper, Schlein, Morten, Steensgaard, Dorte B, Pedersen, Thomas Å, Pettersson, Ingrid, Ludvigsen, Svend, Kjeldsen, Thomas, Jensen, Knud J, Hubálek, František
Formato: Artigo
Idioma:Inglês
Publicado em: Wiley Subscription Services, Inc., A Wiley Company 2013
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3595460/
https://ncbi.nlm.nih.gov/pubmed/23281053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2211
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