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Incomplete TCRβ allelic exclusion accelerates spontaneous autoimmune arthritis in K/BxN TCR transgenic mice
Allelic exclusion of antigen receptor loci is a fundamental mechanism of immunological self tolerance. Incomplete allelic exclusion leads to dual T cell receptor (TCR) expression and can allow developing autoreactive αβ T lymphocytes to escape clonal deletion. Because allelic exclusion at the TCRβ l...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2012
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3594800/ https://ncbi.nlm.nih.gov/pubmed/22706882 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201242520 |
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