Bax Exists in a Dynamic Equilibrium between the Cytosol and Mitochondria to Control Apoptotic Priming

The proapoptotic Bcl-2 protein Bax is predominantly found in the cytosol of nonapoptotic cells and is commonly thought to translocate to mitochondria following an apoptotic stimulus. The current model for Bax activation is that BH3 proteins bind to cytosolic Bax, initiating mitochondrial targeting a...

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Main Authors: Schellenberg, Barbara, Wang, Pengbo, Keeble, James A., Rodriguez-Enriquez, Ricardo, Walker, Scott, Owens, Thomas W., Foster, Fiona, Tanianis-Hughes, Jolanta, Brennan, Keith, Streuli, Charles H., Gilmore, Andrew P.
Format: Artigo
Sprog:Inglês
Udgivet: Cell Press 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3594749/
https://ncbi.nlm.nih.gov/pubmed/23375500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2012.12.022
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