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A novel pathway of presentation by class II-MHC molecules involving peptides or denatured proteins important in autoimmunity

We describe here a pathway of presentation involving peptides or denatured proteins that generate unique peptide-MHC complexes. Such complexes select for non-conventional CD4 T cells. We have examined this pathway and the corresponding CD4 T cells in diabetic autoimmunity. Autoimmunity requires both...

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Détails bibliographiques
Auteurs principaux: Mohan, James F., Unanue, Emil R.
Format: Artigo
Langue:Inglês
Publié: 2012
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3594457/
https://ncbi.nlm.nih.gov/pubmed/23200226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molimm.2012.10.024
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