Elevated rates of force development and MgATP binding in F764L and S532P myosin mutations causing dilated cardiomyopathy

Dilated cardiomyopathy (DCM) is a disease characterized by dilation of the ventricular chambers and reduced contractile function. We examined the contractile performance of chemically-skinned ventricular strips from two heterozygous murine models of DCM-causing missense mutations of myosin, F764L/+...

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Autori principali: Palmer, Bradley M., Schmitt, Joachim P., Seidman, Christine E., Seidman, J. G., Wang, Yuan, Bell, Stephen P., LeWinter, Martin M., Maughan, David W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3594396/
https://ncbi.nlm.nih.gov/pubmed/23313350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2012.12.022
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