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Identification of antifungal natural products via Saccharomyces cerevisiae bioassay: insights into macrotetrolide drug spectrum, potency and mode of action

Since current antifungal drugs have not kept pace with the escalating medical demands of fungal infections, new, effective medications are required. However, antifungal drug discovery is hindered by the evolutionary similarity of mammalian and fungal cells, which results in fungal drug targets havin...

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Bibliografiske detaljer
Main Authors: Tebbets, Brad, Yu, Zhiguo, Stewart, Douglas, Zhao, Li-Xing, Jiang, Yi, Xu, Li-Hua, Andes, David, Shen, Ben, Klein, Bruce
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3594352/
https://ncbi.nlm.nih.gov/pubmed/22928922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/13693786.2012.710917
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