AMP-ACTIVATED PROTEIN KINASE AS REGULATOR OF P2Y(6) RECEPTOR-INDUCED INSULIN SECRETION IN MOUSE PANCREATIC β-CELLS

5’-AMP-activated protein kinase (AMPK) and its pharmacological modulators have been targeted for treating type 2 diabetes. Extracellular uridine 5’-diphosphate (UDP) activates P2Y(6) receptors (P2Y(6)Rs) in pancreatic β-cells to release insulin and reduce apoptosis, which would benefit diabetes. Her...

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Main Authors: Balasubramanian, Ramachandran, Maruoka, Hiroshi, Jayasekara, P. Suresh, Gao, Zhan-Guo, Jacobson, Kenneth A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3594329/
https://ncbi.nlm.nih.gov/pubmed/23333427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2012.11.029
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