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NAD kinase regulates the size of the NADPH pool and insulin secretion in pancreatic β-cells

NADPH is an important component of the antioxidant defense system and a proposed mediator in glucose-stimulated insulin secretion (GSIS) from pancreatic β-cells. An increase in the NADPH/NADP(+) ratio has been reported to occur within minutes following the rise in glucose concentration in β-cells. H...

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Bibliographic Details
Main Authors: Gray, Joshua P., Alavian, Kambiz N., Jonas, Elizabeth A., Heart, Emma A.
Format: Artigo
Language:Inglês
Published: American Physiological Society 2012
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3431206/
https://ncbi.nlm.nih.gov/pubmed/22550069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00465.2011
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