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Rapamycin Reverses Status Epilepticus-Induced Memory Deficits and Dendritic Damage

Cognitive impairments are prominent sequelae of prolonged continuous seizures (status epilepticus; SE) in humans and animal models. While often associated with dendritic injury, the underlying mechanisms remain elusive. The mammalian target of rapamycin complex 1 (mTORC1) pathway is hyperactivated f...

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Hlavní autoři: Brewster, Amy L., Lugo, Joaquin N., Patil, Vinit V., Lee, Wai L., Qian, Yan, Vanegas, Fabiola, Anderson, Anne E.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3594232/
https://ncbi.nlm.nih.gov/pubmed/23536771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0057808
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